Staying ahead of the technology curve means strengthening your competitive advantage. That is why we give you data-driven innovation insights based on our analysis of 1.447 omics startups & technologies. This time, you get to discover 9 omics trends and 9 hand-picked startups advancing the BioTech industry.
Innovation Map highlights Global Omics Technologies & Startups
For this in-depth research on the Top Omics Trends & Startups, we analyzed a sample of 1.400+ global startups and scaleups. These insights are derived by working with our Big Data & Artificial Intelligence-powered StartUs Insights Discovery Platform, covering 2.093.000+ startups & scaleups globally. The platform quickly delivers an exhaustive overview of emerging technologies within a specific field as well as identifies relevant startups & scaleups early on.
In the Innovation Map below, you get an overview of the 9 omics technologies that drive innovation in BioTech. This research gives you data-driven innovation intelligence that improves strategic decision-making by giving you an overview of emerging technologies & startups increasing transparency and productivity.
Omics Technologies & Startups
1. Human Genomics
The cost of sequencing genomes has fallen by orders of magnitude, making DNA sequencing of entire human genomes routine. By comparing genomes across families to populations, startups derive valuable insights to advance preventive and precision medicine. Moreover, these insights also further consumer BioTech applications, such as kits to determine ancestry or what food one should eat. As the applications of human genomics grow, there is a growing need to secure personal genomics data as well. Selected human genomics solutions include:
- Precision Medicine
- DNA Testing Kits
- Preventive Healthcare
- Clinical Genomics
- Secure Genomic Data
Lumminary develops an Ancestry Testing Kit
British startup Lumminary is a one-stop-shop for human genomics services. The startup offers solutions for ancestry DNA testing to reveal family history, going back thousands of years. These include maternal and paternal lineage testing, as well as ancestral origins based on reference populations. Lumminary also provides personalized DNA-based nutrition and fitness recommendations.
Unlike the genome, the proteome differs considerably depending on the cell type and time. This is why BioTech startups are developing more accurate and precise solutions to analyze proteomic changes. This enables applications ranging from diagnostics and immuno-oncology to novel drug targets. The ability to screen large numbers of proteins also enables the quantification of big proteomic data to develop new proteins for industrial applications. Some proteomics solutions include:
- Large-Scale Proteomics
- Functional Diagnostics
- Proteomics-driven Drug Discovery
- Protein Profiling
- Clinical Proteomics
Captor Therapeutics targets the Undruggable Proteome
Captor Therapeutics is a Polish BioTech startup targeting the undruggable proteome. Obteron, the startup’s proprietary platform, discovers therapeutic compounds. The biopharmaceutical candidates target the degradation of specific proteins via the proteasome or the autophagosome. The startup’s drug development activities target autoimmune, inflammatory, and neurodegenerative diseases.
By quantifying gene expression, transcriptomics provides a picture of which genes are expressed and when. Advances in transcriptomics technologies allow researchers to study gene expression across scales ranging from single cells to entire tissues. This is why transcriptomics finds applications across the biomedical and biopharma sectors. It also enables genotype-phenotype comparisons, facilitating molecular breeding initiatives. Some transcriptomics use cases include:
- Single-Cell Transcriptomics
- Nanopore RNA Sequencing
- Spatial Transcriptomics
- Liquid Biopsies
- Differential Gene Expression Analysis
Scipio Bioscience enables Single-Cell Transcriptomics
French startup Scipio Bioscience develops solutions for single-cell transcriptomics. The startup’s proprietary technology simplifies the preparation of samples for single-cell profiling. The benchtop kit extracts messenger RNA (mRNA) from single cells. It then combines biochemical and biophysical techniques to enable single-cell barcoding in a test tube format.
Epigenomics underlines how two people – even identical twins – react differently to different products, whether it is drugs, food, or cosmetics. BioTech solutions are working on epigenetics and epigenomics to bridge this gap in understanding. Such solutions quantify the effect of lifestyle and environmental factors on individual health and aging. Moreover, startups identify epigenetic modulators as biomarkers to develop better drugs and assays. Some epigenomics solutions include:
- Histone Modification Assays
- Personal Epigenomics Testing
- Preventive Medicine
- Epigenetic Biomarkers
- Epigenetic Drug Discovery
Epify develops Epigenetic Biomarkers
Epify is a Dutch startup developing epigenetic biomarkers for cancer diagnosis. The startup’s solutions detect different kinds of epigenetic modifications, including DNA methylations, histone modifications, and RNA transcript modifications. It helps companies set up their biomarker discovery pipelines, or use Epify’s biomarkers, to develop their diagnostic tests. Moreover, it also aids the development of clinical practices that leverage epigenomics.
Going beyond nucleic acids and proteins, small molecules also play a significant role in biological systems. Many of these, such as antibiotics, amino acids, and pigments, already find applications across the BioTech industry. With the development of high-throughput screening solutions, BioTech startups and companies alike are discovering more metabolites with desired properties. Some metabolomics applications include:
- Exposure Monitoring
- Bioprospecting Bacterial Metabolites
- Metabolic Biomarkers
- Phytochemical Analysis
- Personalized Metabolic Profiling
Million Marker develops an Exposure Monitoring Kit
Million Marker is a US-based startup offering an exposure monitoring kit. The startup sends a urine sample collection kit, allowing users to either mail it back or schedule a pick-up. It then performs metabolomic analysis on the samples to measure individuals’ exposure to environmental toxins. Subsequent testing allows individuals to monitor changes in their exposomes over time.
Microbial diversity continues to translate into valuable products for the BioTech industry. Moreover, in recent years, there has been significant work towards elucidating the role of the microbiome in human health and agriculture. However, most microbes are difficult or impossible to culture in labs. Metagenomics solutions analyze the presence of microbes, as well as what roles they play, in different biological systems such as the gut, skin, or soil. Some metagenomics solutions include:
- Metagenomic Screening
- Precision Microbiomics
- Environmental DNA (eDNA) Monitoring
- Antibiotic Resistance Monitoring
- Development of Gene Editing Tools
Precision Biomonitoring offers Environmental DNA Monitoring Solutions
Precision Biomonitoring is a Canadian startup that provides on-site molecular testing solutions. The startup’s TripleLock platform enables accurate quantitative polymerase chain reaction (qPCR) assays for field samples. Three9, the startup’s handheld portable device, provides rapid on-site testing. The startup also provides solutions for public health, agrifood, and other environmental monitoring needs.
Glycans play crucial roles in all kinds of cells and thereby hold promise for a range of BioTech applications, including in biofuels, food, and materials. However, until recently, quantification and custom synthesis of glycans were prohibitively expensive. BioTech startups are developing glycomics solutions that overcome these challenges to develop a range of diagnostic and therapeutic products. Some glycomics solutions include:
- Glycan Quantification
- Bacterial Diagnostics
- Anticancer Therapeutics
- Microbiome Modulators
- Novel Ingredients
BCD Bioscience formulates Novel Ingredients
US-based startup BCD Bioscience creates novel ingredients for food, agriculture, and biopharma applications. The startup’s proprietary technology breaks down polysaccharides into oligosaccharides. It then assays its oligosaccharides for selective microbial growth, metabolic output, and effect on the gut barrier infection. Lastly, it uses bioinformatics tools and phenotyping screening to pair glycans with single microbial strains.
Different people react to the same drug differently. Drugs that are ineffective for some patient subgroups lower patient outcomes, as well as lead to high medical costs and adverse events. That is why pharmacogenomics solutions analyze gene-drug interactions to enable the transition from a ‘one drug fits all’ approach to a more patient-oriented approach. Along with other omics technologies, it is enabling the rise of predictive, preventive, personalized, and participatory (P4) medicine. Some pharmacogenomics use cases include:
- Personalized Dosing
- Precision Medicine
- Phenome Analysis
- Preventative Treatment
- Pharmacogenomic Testing
Nalagenetics develops Personalized Dosing Solutions
Singaporean startup Nalagenetics offers personalized dosing and prescription solutions. The startup’s pharmacogenomics kit provides actionable insights on the use of up to 159 different drugs. These include medications for a wide range of conditions, including cardiac, pain, gastric, and other chronic disorders. The startup provides post-test counseling and a mobile app for continuous support to ensure better decisions for current and future prescriptions.
Multiomics, also known as panomics or integrative omics, combines two or more of the omics technologies mentioned above. Integrating multiple layers of biological information in this way provides deep insights into how biological systems work. Modeling these systems with quantitative tools enables the development of more sensitive diagnostics and translational therapeutics. Some of the applications of multiomics include:
- Blood Diagnostics
- Tertiary Analysis
- Translational Therapeutics
- Preventive Health Interventions
- Biological Systems Modeling
Govita Tech enables Preventive Health
Chinese startup Govita Tech develops molecular biomarker panels for preventive health applications. The startup combines genomics, metabolomics, and bioinformatics to interpret phenotype from genotype, predicting disease risk. It then recommends interventions and health plans that reduce the risk of disease onset. The startup’s solutions integrate multiomics and clinical phenotyping to provide insights into health and aging.
Discover the Latest Omics Startups
Every day, new startups and technologies emerge that advance omics technologies. These solutions span a range of applications across the BioTech and related industries, and emerging companies often use them in combination with other emerging BioTech trends. As most startups and scaleups analyze proteins, transcripts, metabolites, etc in human systems, many of these solutions further progress in the biomedical and biopharma sectors. However, glycomics, metagenomics, and multiomics solutions enable the identification and development of novel microbial communities or their products for use across the industry. As prices of omics screening continue to fall, expect more applications in personal health and consumer BioTech.
Get in touch to identify specific startups & solutions that help your BioTech business generate and leverage large amounts of biological information.