5 Top Medical Device Startups Impacting the Healthcare Sector

We analyzed 2.969 MedTech startups developing novel medical devices. Curiteva, Puzzle Medical Devices, Reprise Bio, Paragate Medical & Acurable develop 5 top solutions you should watch out for. Learn more in our Global Startup Heat Map!

Our Innovation Analysts recently looked into emerging technologies and up-and-coming startups working on innovative solutions in the healthcare sector. As there is a large number of startups working on a wide variety of solutions, we decided to share our insights with you. This time, we are taking a look at 5 promising medical device startups.

Heat Map: 5 Top Medical Device Startups

Using our StartUs Insights Discovery Platform, covering 1.379.000+ startups & scaleups globally, we looked at innovation in the field of healthcare. For this research, we identified 2.969 relevant solutions and picked 5 to showcase below. These companies were chosen based on a data-driven startup scouting approach, taking into account factors such as location, founding year, and relevance of technology, among others. Depending on your specific criteria, the top picks might look entirely different.

The Global Startup Heat Map below highlights 5 startups & scaleups developing innovative medical device solutions. Moreover, the Heat Map reveals regions that observe a high startup activity and illustrates the geographic distribution of all 2.969 companies we analyzed for this specific topic.


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Which startups develop the other 2.964 solutions?


Curiteva – Spinal Implant

Medical procedures require the help of external devices to either monitor, correct, or act as a support structure. Especially in cases of spinal injury, the patient has a high chance of losing motor skills as the spine is connected to the central nervous system. Novel materials innovations enable medical device manufacturers to develop safe and biocompatible implants to enhance healthcare delivery. Startups develop spinal implants to correct sports injuries and to treat other major trauma patients.

The US-based medical technology startup Curiteva develops advanced spinal implant systems. Aptitude, the startup’s standard, and midline anterior cervical plate system is simple to use and has a one-step locking mechanism to enable surgeons to have better control during the procedure. The startup also offers pedicle screws for use in spinal fusions that adds extra support and strength to the spinal fusion while healing. Curiteva’s medical device portfolio includes cervical interbody fusion systems that are manufactured with both titanium and PEEK, a biocompatible polymer.

Puzzle Medical Devices – Minimally-Invasive Heart Pump

Heart failure is one of the most common causes of death around the world. Acute cardiac conditions involve complicated surgeries and high costs for both the patient and the hospital management. Medical device innovations in implants, pumps, and bone joints enable the development of novel cardiovascular devices. Startups and scaleups develop minimally-invasive cardiac solutions to decrease mortality rates arising from heart-related problems.

Canadian startup Puzzle Medical Devices produces minimally-invasive hemodynamic transcatheter heart pumps. The startup combines advances in heart surgery and interventional cardiology to render safe and accessible hemodynamic support. Moreover, Puzzle Medical has successfully completed the in-vivo preclinical implantations.

Reprise Bio – Biological Medical Device

Conventional soft tissue regeneration solutions take a significant amount of time to effectively treat issues. Since the pig and the human are a sufficient genetic match, the use of porcine liver tissue in humans is under investigation in the biotech industry. Startups develop biological medical devices, such as cellular matrices, to help treat soft tissue regeneration and external wounds in patients.

The US-based startup Reprise Bio creates MiroMesh, a biological medical device to reinforce soft tissue. With the help of a highly vascularized porcine liver, the startup develops MiroMesh. The startup’s perfusion decellularization technology enables rapid access to the entire organ. Reprise Bio has clinically tested MiroMesh in repairing the hiatal and paraesophageal hernia complications. The startup’s solution is an open collagen matrix with natural vascular pathways that is also scalable in terms of size by simply combining more pieces of MiroMesh.

Paragate Medical – Implant for Kidney Support

Diabetes, high blood pressure, and injuries cause the kidneys to malfunction and results in problems such as acute kidney failure. Technological advances in medical devices such as targeted dialysis help support the kidneys to an extent but still requires regular hospital visits for the procedure. Startups develop implantable devices that support kidney functioning and help remove the wastes in the bloodstream.

Israeli startup Paragate Medical provides an implantable device to treat cardiac and kidney patients suffering from fluid overload. The startup’s implantable peritoneal ultrafiltration device (IPUD) is a minimally-invasive and fully-implantable device that serves as a mechanical support system to the kidneys, continuously and non-aggressively removing excess fluid from the body. This results in the slow drainage of excess isotonic systemic fluids, that is fully independent of the kidney.

Acurable – Medical Device for Sleeping Disorders

Normally, snoring is associated with obstructive sleep apnoea (OSA) but not all people who snore have OSA. This is a serious medical condition where breathing repeatedly starts and stops. Advancements such as continuous positive airway pressure machines help patients sleep without any discomfort. Startups develop medical device solutions to monitor and regulate breathing patterns for patients to sleep better.

British startup Acurable offers the AcuPbble SA100, a medical device for automated diagnosis of obstructive sleep apnoea. With the help of a medical sensor, the patients track their sleep cycles and also receive automated reports. Doctors later analyze the clinical evidence gathered by AcuPebble to provide the appropriate care plan for patients.

What about the other 2.964 solutions?

While we believe data is key to creating insights it can be easy to be overwhelmed by it. Our ambition is to create a comprehensive overview and provide actionable innovation intelligence and enable you to achieve your goals faster. The 5 medical device startups showcased above are promising examples out of the 2.969 we analyzed for this article. To identify the most relevant solutions based on your specific criteria, get in touch.

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