The USA hosts nearly 70 000 startups in the healthcare, manufacturing, e-commerce, fintech, and robotics sectors. This article highlights key technologies and trends while focusing on the ecosystem’s early-stage support and agile companies with an average of 16 employees.
It explores how this environment creates opportunities for strategic partnerships, innovation, and market disruption. Further, the article offers valuable insights for investment, collaboration, and market entry in a rapidly evolving landscape.
9 American Startups to Watch in 2025
- Savvi AI – AI-based Fintech Platform
- Telepath – Auto-Generated ML Models
- Hohonu – Real-Time Water Data Insights
- Simplex Wireless – IoT Connectivity Platform
- Mujin – Industrial Robotic Controllers
- Vzense – Time-of-Flight Camera
- Alta Biomaterials – Polymer Surface Coating
- WePower – Energy Harvesting from Motion
- Torus – Integrated Energy Storage and Management
Global Startup Heat Map highlights 9 American Startups to Watch
Through the Big Data & Artificial Intelligence (AI)-powered StartUs Insights Discovery Platform, covering over 4 760 120+ startups & scaleups globally, we identified 69 860+ startups. The Global Startup Heat Map below highlights the 9 American startups you should watch in 2025 as well as the geo-distribution of all 69 860+ startups & scaleups we analyzed for this research.
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Based on the heat map, we see high startup activity in California and Georgia, followed by New York. These 9 startups work on solutions ranging from biocomposites and AI models for finance to nanomaterials and robotic controllers.
As the world’s largest resource for data on emerging companies, the SaaS platform enables you to identify relevant technologies and industry trends quickly and exhaustively. Based on the data from the platform, the Top 5 American Startup Hubs are in California, Georgia, New York, and Utah. The 9 hand-picked startups highlighted in this report are chosen from all over the world and develop solutions for biomaterials, IoT connectivity, energy harvesting, and robotic controllers.
Explore 9 American Startup Companies to Watch in 2025
1. Savvi AI
- Founding Year: 2020
- Location: Chicago, IL, USA
- Solution: AI-based Fintech Platform
Savvi AI develops an AI-based fintech platform that helps businesses build, launch, and manage AI applications. It functions without data scientists or custom infrastructure.
The platform integrates into tools like Excel or Google Sheets, as well as via API to automate forecasts and recommendations. Savvi AI also generates machine learning models for predicting loan risks, forecasting deposits, or increasing loan uptake.
2. Telepath
- Founding Year: 2020
- Location: Los Angeles, California, USA
- Solution: Auto-Generated ML Models
Telepath develops an auto-generated machine-learning model platform that enables developers to build custom models. The platform works by allowing users to connect their database data directly to the Telepath system. It then reads the training data, auto-generates a custom model, and deploys it as an API for real-time predictions.
It also features the use of declarative code to define project resources, fully managed serverless hosting, and explainability that enables users to understand model decisions. Additionally, Telepath simplifies machine learning for developers, enabling quick integration of predictive capabilities into applications without requiring complex infrastructure or data science expertise.
3. Hohonu
- Founding Year: 2020
- Location: Honolulu, Hawaii, USA
- Solution: Real-Time Water Data Insights
Hohonu provides precision water level monitoring and forecasting technology for communities to prepare for and respond to flooding. The startup deploys solar-powered sensors that measure tides every second and offer real-time data through its user-friendly mobile application. Hohonu’s system features a quick installation process, a low-profile design, and ultra-low power consumption.
The technology incorporates machine learning algorithms to generate accurate 72-hour water level predictions, significantly improving upon traditional tidal forecasts. Hohonu’s platform offers road flooding detection, customizable alert systems, and flood reporting and analysis tools.
Also, Hohonu is deploying water sensors in Chesapeake Bay, funded by a University of Maryland grant, to support flood resilience.
4. Simplex Wireless
- Founding Year: 2022
- Location: Alpharetta, Georgia, USA
- Solution: IoT Cellular Connectivity
Simplex Wireless provides a global IoT cellular connectivity platform for commercial applications. The startup’s technology utilizes existing industry components and integrates them into a unified system that offers connectivity across various regions and networks. Simplex’s platform features an intuitive dashboard that allows users to activate devices, manage connections, and access real-time data.
The system supports a wide range of IoT devices and use cases, from asset tracking to smart city applications, enabling businesses to deploy and scale their IoT solutions efficiently.
Additionally, Simplex Wireless announced a major partnership with Simetric which is a leading IoT cross-carrier SaaS platform.
5. Mujin
- Founding Year: 2021
- Location: Suwanee, Georgia, USA
- Solution: Industrial Robotic Controllers
Mujin develops a robotic controller that manages diverse robotic applications through artificial intelligence and autonomous motion planning. The Mujin Controller interfaces with various robot arms that enable users to define specific applications and select the most suitable robotic hardware for their needs.
This technology employs a proprietary motion planning algorithm that calculates the most efficient path for robots to perform a wide range of tasks. Mujin’s vision systems and end-of-arm tooling allow for adaptability across different applications and environments.
Accenture along with Mujin establishes a joint venture to bring AI and robotics to the manufacturing and logistics industries
Interested in exploring all 69K+ USA-based startups & scaleups?
6. Vzense
- Founding Year: 2020
- Location: Newark, CA, USA
- Solution: Time-of-flight Camera
Vzense develops time-of-flight (ToF) 3D sensors and people-counting systems for consumer, commercial, and industrial applications. The startup’s technology utilizes ToF principles that emit light signals and measure the time they take to return to calculate precise depth information and create detailed 3D maps of environments.
Vzense’s sensors offer high accuracy and resolution, even in challenging lighting conditions, making them suitable for a wide range of applications, including robotics, autonomous vehicles, smart retail, and industrial automation. Vzense’s people counting systems leverage this 3D sensing technology to provide accurate crowd analytics and foot traffic data.
7. Alta Biomaterials
- Founding Year: 2023
- Location: Carlsbad, California, USA
- Solution: Polymer Surface Coating
Alta Biomaterials develops the proprietary Polyzene-F nanocoating for medical devices to enhance their interaction within the body. The biomaterial nanocoating works by forming a nano-thin barrier between the medical device and surrounding tissues. It also reduces inflammation, minimizes thrombosis, and promotes rapid healing.
The coating is compatible with various materials such as metals and polymers suitable for use in implants like stents, microspheres, and surgical meshes. It improves biocompatibility due to its anti-thrombogenic and anti-inflammatory properties.
8. WePower
- Founding Year: 2019
- Location: Sagaponack, New York, USA
- Solution: Energy Harvesting from Motion
WePower develops an energy harvesting platform called Gemns, which uses electromagnetic induction to generate power for IoT and IIoT devices. It converts kinetic energy from a button press or vibration into electrical energy using permanent magnets and coils.
This energy operates sensors and transmitters which eliminates the need for traditional batteries. The Gemns energy harvesting generators offer higher energy output than the extended RF range which increases reliability.
9. Torus
- Founding Year: 2021
- Location: South Salt Lake, Utah, USA
- Solution: Integrated Energy Storage and Management
Torus develops Torus Nova, an energy storage and management system that enables clean energy generation and storage. The system integrates renewable energy sources like solar panels, and wind turbines for storing energy in the battery system.
Torus Overwatch monitors assets and improves the performance of operation and maintenance systems. Additionally, Torus Lasso facilitates scheduling and dispatching through the use of AI-driven asset management across fleets and generation resources.
Moreover, Torus Robotics raised USD 470 000 in seed funding led by TNIFMC to advance its indigenous EV powertrain technology.
Discover All Emerging USA-based Startups
The 69K+ USA-based startups showcased in this report are only a small sample of all startups we identified through our data-driven startup scouting approach.
Download our free Industry Innovation Reports for a broad overview of the industry or get in touch for quick & exhaustive research on the latest technologies & emerging solutions that will impact your company in 2025!
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