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Organ on a chip companies are revolutionizing how researchers study human biology, test drugs, and develop personalized treatments. These microfluidic devices simulate real organ functions using human cells, allowing for precise modeling of physiological conditions.
From AI-powered automation and tumor-specific platforms to neuron and cartilage chips, these innovations enable faster, more predictive, and ethically aligned biomedical research.
In this article, we spotlight 10 emerging startups in 2025 that are transforming preclinical testing and therapeutic development through scalable, high-fidelity organ-on-a-chip systems.
Global Startup Heat Map highlights Emerging Organ on a Chip Startups to Watch
Through the Big Data & Artificial Intelligence (AI)-powered StartUs Insights Discovery Platform, covering over 7M+ startups, 20K+ technology trends, plus 150M+ patents, news articles & market reports, we identified 10 organ on a chip solutions advancing last-mile delivery startups.
The Global Startup Heat Map below highlights the organ on a chip solutions advancing last-mile delivery companies you should watch in 2025, as well as the geo-distribution of 100 startups & scaleups we analyzed for this research.
According to our data, we observe high startup activity in the US and UK, followed by Germany. The top 5 startup hubs for organ-on-a-chip solutions advancing last-mile delivery are London, New York City, Bangalore, Mountain View, and Boston.
Explore Emerging Organ on a Chip Companies to Watch in 2025
We hand-picked startups to showcase in this report by filtering for their technology, founding year, location, funding, and other metrics. These organ on a chip solutions work on solutions ranging from precision drug discovery and personalized oncology to cell & gene therapy and AI-integrated organ simulation.
- VitrofluidiX – Organ-on-a-Chip Device
- Anivance AI – AI Agent-Powered Organ-on-a-Chip
- PlusTen Intelligence – Neuron-on-Chip Platform
- CanChip – Tumor-on-a-Chip Platform
- 7 Talos – CAR-T Cell Manufacturing Platform
- chiron – Cartilage-on-Chip Platform
- Pythia Biotech – Liver-on-a-Chip Solution
- Pre-Cure – Tumor-on-a-Chip for Personalized Oncology
- OrganoBiotech – Modular Organ-on-a-Chip Models
- Humanase – Brain-on-a-Chip for Neurological Drug Testing
1. VitrofluidiX
- Founding Year: 2024
- Location: Cologne, Germany
- Use For: Organ-on-a-chip Device
German startup VitrofluidiX develops an organ-on-a-chip device that stimulates any organ by controlling all parameters in customizable single- or multi-organ chip formats.
This device integrates live microscopy, integrated incubation, and automated media handling for real-time observation with minimized contamination during experiments.
Moreover, this solution enables scientists to study highly realistic models of tissues and diseases while working directly with human cells. Further, it allows them to adjust material selection and chip design to match specific study requirements.
2. Anivance AI
- Founding Year: 2024
- Location: Hsinchu, Taiwan
- Use For: AI agent-powered OoC
Taiwan startup Anivance AI builds an AI-driven organ-on-a-chip platform that leverages large language models (LLMs) and adaptive data systems to automate experimental workflows across drug discovery.
The system builds a scalable pipeline for a wide range of organ-on-chip applications that enables continuous feedback and real-time adjustments from preclinical research through to clinical translation.
The platform enables high-throughput testing and captures dynamic biological responses under clinically relevant conditions.
3. PlusTen Intelligence
- Founding Year: 2024
- Location: Mountain View, California, US
- Use For: Neuron-on-chip Platform
US-based startup PlusTen Intelligence develops a neuron-on-chip platform that uses living neurons to record electrical and chemical signals for brain-computer interfaces, organoid sensing, and biomolecule detection.
This solution replaces electrodes with axons while increasing signal density and removing biocompatibility challenges. It programs the neurons to detect specific molecules.
The platform also integrates with standard lab equipment and enables real-time monitoring of neural activity. This makes it relevant for businesses working in drug discovery, neurotechnology, and synthetic biology that seek biologically accurate signal acquisition without complex hardware or workflow.
4. CanChip
- Founding Year: Potsdam, Germany
- Location: 2023
- Use For: Tumor-on-a-Chip
German startup CanChip develops tumor-on-a-chip platforms that replicate human tumor microenvironments for cancer research. The technology integrates microfluidic systems with 3D bioprinting to mimic structural and physiological conditions like cell-cell interactions, fluid dynamics, and nutrient gradients.
Its modular design featuring components like bioprinting chips, porous membranes, and cell-free chips enables researchers to customize experiments for different cancer types and therapeutic targets. This enhances reproducibility and relevance in drug testing.
5. 7 Talos
- Founding Year: 2023
- Location: Barcelona, Spain
- Use For: CAR-T Cell Manufacturing
Spanish startup 7Talos develops a decentralized CAR-T cell manufacturing platform that integrates organ-on-chip and lab-on-chip technologies with AI, image recognition, multi-omics analysis, and robotics.
The system replicates human biological conditions on microfluidic chips to monitor and guide cell development processes inside bioreactors.
This setup enables real-time observation, localized production, and adaptive adjustments based on patient-specific data. Its modular design allows for shorter production cycles, reduced costs, and improved responsiveness in clinical settings.
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6. chiron
- Founding Year: 2022
- Location: Maastricht, Netherlands
- Use For: Cartilage-on-Chip Platform
Netherlands-based startup chiron develops a cartilage-on-chip platform that models human joint tissue using microfluidic devices with mechanical stimulation and real-time imaging for drug testing applications.
The technology incorporates human chondrocytes into a controlled environment that simulates joint motion and enables researchers to monitor cellular behavior under physiologically relevant stress.
It combines visual monitoring with reproducible mechanical cues for data consistency and avoids reliance on animal models. The startup provides pharmaceutical teams with earlier access to human-specific insights that improve drug evaluation.
7. Pythia Biotech
- Founding Year: 2022
- Location: Taipei City, Taiwan
- Use For: Liver Chip
Taiwan startup Pythia Biotech develops a liver-chip that uses dielectrophoresis to guide liver cells into organized 3D chambers for in vitro tissue culture.
The chip combines MEMS engineering with biological techniques to recreate essential liver functions, such as enzyme activity and metabolic secretion, within a controlled microenvironment.
Its design enables realistic nutrient flow and cellular interaction for accurate results. The startup provides a physiologically relevant model that improves the prediction of liver response to pharmaceutical compounds.
8. Pre-Cure
- Founding Year: 2022
- Location: Jerusalem, Israel
- Use For: Tumor-on-a-Chip Platform
Israel-based startup Pre-Cure utilizes customized microfluidics tumor-on-a-chip technology to accelerate cancer treatment. This solution determines the most suitable treatment and dosage for patients with solid tumors.
It primarily focuses on the types of tumors, such as gastrointestinal, gynecological, and head and neck cancers, utilizing biopsy samples. Further, the startup employs 3D printing technology to produce microfluidic biochips customized for drug testing.
9. OrganoBiotech
- Founding Year: 2021
- Location: Hamilton, Canada
- Use For: Organ-on-a-Chip Models
Canadian startup OrganoBiotech develops organ-on-a-chip models to improve the relevance of preclinical drug testing. Its platform creates 3D tissue cultures by combining microfluidic systems with modular design. This allows researchers to model specific organs and physiological processes.
The solution supports organo assays, which simulate chronic and multifactorial diseases. Further, it allows for tissue-specific customization, compatibility with standard lab equipment, and integration with machine learning to enhance data analysis.
10. Humanase
- Founding Year: 2021
- Location: Seongnam, South Korea
- Use For: Brain-on-a-chip
South Korean startup Humanase develops a brain-on-a-chip platform that uses human iPSC-derived neuronal cells and astrocytes to evaluate drug efficacy and toxicity.
The technology models human brain environments by co-culturing these cell types that enable the study of cellular interactions under disease-relevant and experimental conditions.
It helps research on neurodegenerative diseases such as Alzheimer’s and Parkinson’s while removing the need for complex lab setups. Humanase offers a practical tool for researchers and drug developers for predictive and neurological drug testing.
Discover All Emerging BioTech Startups
The BioTech startups showcased in this report are only a small sample of all startups we identified through our data-driven startup scouting approach. Download our free BioTech Innovation Report for a broad overview of the industry or get in touch for quick & exhaustive research on the latest technologies & emerging solutions that will impact your company in 2025.
