10 Top Real World Evidence Companies and Startups to Watch in 2026

Iryna Bursuk

Iryna Bursuk

Last updated: August 16, 2025

Curious about startups that will impact the healthcare industry? Discover 10 hand-picked Real World Evidence Startups to Watch in 2025 in this report & learn what their solutions have in store for your business!

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Executive Summary: Which are the Top 10 Real World Evidence Companies to Watch?

  1. KolateAI PharmaTech (US): AI-powered clinical events prediction engine using multimodal real world and trial data.
  2. Century Health (US): AI-driven real world evidence platform analyzing longitudinal clinical data.
  3. Traverse Health (Netherlands): Observational medical outcomes partnership (OMOP)-based federated platform structuring hospital data into anonymized, cloud-ready datasets
  4. Okeiro (France): Precision medicine platform using validated algorithms like iBox
  5. RemedyBytes (Finland): Analytics engine sourcing registry-verified data to provide standardized, cross-country healthcare insights for pharmaceutical strategy.
  6. Carelane (Germany): fast healthcare interoperability resources (FHIR)-based clinical trial platform unifying data from electronic health records (EHRs), wearables, and patient-reported outcomes (PROs) into a single, automated interface
  7. iksa.ai (India): AI operating layer that embeds policy-compliant agents into existing healthcare workflows to automate insights and enforce clinical governance.
  8. CorpusAnalytiX (UK): Multi-omics data brokerage platform connecting researchers to molecular and population-level datasets via a compliant, unified access ecosystem.
  9. eMed Support Systems (UAE): AI-driven cardiovascular digital twin platform combining voice input and EHRs to predict risks, guide treatment, and enable real-time patient tracking.
  10. Genoplex.ai (US): Cloud-native AI engine matching diagnostics with trials and therapies.

Global Startup Heat Map highlights Emerging Real World Evidence Companies to Watch

Through the Big Data & Artificial Intelligence (AI)-powered StartUs Insights Discovery Platform, covering over 7M+ startups, 20K+ technology trends plus 150M+ patents, news articles & market reports, we identified 10 real world evidence startups.

The Global Startup Heat Map below highlights emerging real world evidence solutions you should watch in 2026 as well as the geo-distribution of 400+ startups & scaleups we analyzed for this research.

According to our data, we observe high startup activity in the USA and India, followed by the UK. The top 5 Startup Hubs for real world evidence are London, San Francisco, New York City, Bangalore, and Boston.

 

Explore Emerging Real World Evidence Companies to Watch in 2026

We hand-picked startups to showcase in this report by filtering for their technology, founding year, location, funding, and other metrics. These emerging real world evidence startups work on solutions such as AI-driven clinical events prediction engines, AI-powered cardiovascular digital twins, patient diagnostic information analysis software, and much more.

1. KolateAI PharmaTech

  • Founding Year: 2023
  • Location: Belle Mead, US
  • Use For: AI-driven Clinical Events Prediction Engine
  • Prominent Partnerships: Resident Company of Johnson & Johnson Innovation JLABS @ NYC, Microsoft for Startups, NJEDA

US-based startup KolateAI PharmaTech designs an AI-driven clinical events prediction engine to process patient-level data from real-world sources and clinical trials. It uses therapeutic-area-specific foundation models to forecast outcomes such as drug response, adverse events, serious adverse events, and study endpoints .

Then it equips clinical and scientific teams with an interactive co-pilot chatbot and dashboard interface for real-time insight queries . Moreover, it integrates diverse real-world and trial data, applies proprietary modeling techniques, and supports comparison of treatment options to inform trial direction and precision targeting .

2. Century Health

  • Founding Year: 2023
  • Location: Santa Monica, US
  • Use For: AI-powered Patient Registry
  • Funding: Raised USD 2 million in Pre-Seed Funding

US-based startup Century Health develops an AI-powered patient registry that accelerates the discovery and recruitment of eligible participants for clinical trials. It aggregates and processes data from diverse sources, including electronic health records, genomic datasets, and real-world evidence, using machine learning algorithms to match patients to study criteria with high precision.

The platform applies NLP to unstructured clinical notes, extracts relevant medical insights, and continuously updates patient profiles as new data becomes available. By integrating longitudinal health records with advanced analytics, it enables researchers to identify rare disease populations, optimize trial site selection, and monitor patient outcomes over time.

3. Traverse Health

  • Founding Year: 2023
  • Location: Amsterdam, Netherlands
  • Use For: Clinical Data Platform
  • Prominent Partnerships: InterSystems, Acibadem

Dutch startup Traverse Health provides a healthcare real world evidence platform that structures clinical data from partner hospitals using the OMOP common data model. It organizes data on-premise at the hospital level, restructures it into an internal data lake, and uploads only anonymized and approved datasets to the cloud for study-specific analysis.

Moreover, the platform operates across a federated data network and enables both cloud and hybrid deployment to ensure compliance with data privacy and regulatory standards. It includes features like disease-specific data models, integration with ongoing studies, and compatibility with synthetic control arms for trial optimization.

4. Okeiro

  • Founding Year: 2023
  • Location: Paris, France
  • Use For: Transplant & Chronic Diseases Precision Medicine
  • Funding: Raised EUR 10 million

French startup Okeiro develops a precision medicine platform that generates real world evidence for transplant and chronic disease care through validated predictive algorithms. The platform collects and analyzes multidimensional patient data at the point of care to assess treatment efficacy and long-term outcomes in routine clinical settings.

Moreover, the platform includes tools like the iBox algorithm for kidney transplant trials, which predicts graft survival and enables earlier regulatory decisions. It reduces follow-up times, targets specific subpopulations using digital twins, and streamlines therapeutic development across nephrology, cardiology, hepatology, and pulmonology.

5. RemedyBytes

  • Founding Year: 2023
  • Location: Helsinki, Finland
  • Use For: Healthcare Data Acquisition

Finnish startup RemedyBytes offers healthcare statistics derived from real world data to improve pharmaceutical decision-making. It sources verified data from national healthcare registries to streamline data acquisition and delivery. The startup structures its workflows to reduce time spent navigating fragmented healthcare data systems.

Moreover, it provides verified insights into market size, treatment pathways, and drug usage by indication. This output supports evidence-based evaluations and operational planning in pharmaceutical settings.

 

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6. Carelane

  • Founding Year: 2023
  • Location: Bremen, Germany
  • Use For: HL7 FHIR-based Platform
  • Funding: Raises EUR 800K in Pre-Seed Funding

German startup Carelane provides a health level 7 (HL7) FHIR-based platform for real world evidence research by eliminating the need for multiple software systems. It collects data from electronic health records, wearable devices, and patient-reported outcomes through standardized FHIR APIs. Moreover, it consolidates protocol authoring, participant management, and site operations into a single interface.

The platform offers self-service design templates and automated workflows, thereby reducing software fragmentation and improving data quality. Carelane helps small biopharma firms execute cost-efficient studies and large health systems coordinate many trials per year with standardized workflows. This solution centralizes trial operations into one secure environment to accelerate evidence generation and maintain regulatory compliance.

7. iksa.ai

  • Founding Year: 2023
  • Location: Mumbai, India
  • Use For: Clinical Context Platform

Indian startup iksa.ai develops a clinical context platform that unifies healthcare data and orchestrates AI-driven workflows across existing systems. It connects to electronic health records, laboratory systems, claims databases, medical devices, and clinical trial platforms through secure, vendor-neutral connectors. It then applies AI modules to automate clinical tasks, structure data, and provide real-time insights.

Its engines include Follow-Up Coach for patient communication, Safety Triage for adverse-event screening, Inbox Router for alert management, Trial Monitor for query resolution, and Revenue Integrity for prior-authorization preparation and denial-risk detection. These are integrated without new applications. It processes data within the customer’s environment and applies a multi-agent guardrail framework to check privacy, bias, and clinical accuracy.

8. CorpusAnalytiX

  • Founding Year: 2024
  • Location: London, UK
  • Use For: Healthcare Data Brokerage Platform

UK-based startup CorpusAnalytiX offers a healthcare data brokerage platform that simplifies knowledge-sharing and provides molecular-level insights through multi-omics datasets for advanced therapeutic development.

It continuously monitors the data for population health insights and behavioral analytics. Further, the startup connects life science researchers directly with data suppliers via an integrated ecosystem that standardizes permissions, negotiates access terms, and unifies fragmented healthcare data.

It aggregates whole-exome sequencing profiles for a large number of genes, tissue whole slide images, HIPAA-compliant de-identified electronic health records, and tumor data lakes with diverse genomic profiles.

9. eMed Support Systems

  • Founding Year: 2023
  • Location: Dubai, UAE
  • Use For: AI-powered Cardiovascular Digital Twin
  • Funding: USD 2.5 M in Seed Funding
  • Revenue: USD 3.66 M Planned Revenue as per 2024
  • Prominent Partnerships: Dubai Science Park, in5 Innovation Centers, InterSystems, NVIDIA

UAE-based startup eMed Support Systems provides an AI-powered cardiovascular digital twin that processes EHR records and voice assistant inputs with a large clinical model to create virtual patient replicas.

The solution predicts missing biomarkers (low-density lipoprotein cholesterol (LDL-C), glomerular filtration rate (GFR), ejection fraction (EF)), flags high-risk patients, and guides voice-driven data capture for early detection of cardiovascular risks.

 

 

Further, the digital twin generates personalized treatment plans, tracks therapy goals, and streamlines medication procurement. Thus, the startup equips general practitioners, cardiologists, clinics, and health authorities with real world evidence and AI insights that prevent myocardial infarction, stroke, and hospitalizations while optimizing care quality and cost efficiency.

10. Genoplex.ai

  • Founding Year: 2023
  • Location: Boulder, US
  • Use For: Advanced Therapy Referral Platform

US-based startup Genoplex.ai delivers an AI-powered referral platform for advanced therapies. It applies a cloud-based data engine that ingests patient diagnostic information and matches it to approved advanced medicines, such as cell therapies, gene therapies, bispecific antibodies, antibody-drug conjugates, and radioligand treatments, at nearby accredited treatment centers.

The solution reduces delays by simplifying referral logistics, streamlining appointment scheduling, and enabling automated treatment notifications, thus supporting faster intake and improving patient experience. It also equips hospitals and life science companies with real-world referral insights for improved forecasting, capacity planning, and care coordination.

Discover All Emerging Real World Evidence Startups

The emerging real world evidence startups showcased in this report are only a small sample of all startups we identified through our data-driven startup scouting approach. Download our free Industry Innovation Reports for a broad overview of the industry or get in touch for quick & exhaustive research on the latest technologies & emerging solutions that will impact your company in 2025!