Discover 5 Top Protein Engineering Startups

Curious about new innovative advancements in biotechnology? Explore our analysis of 166 global protein engineering startups & scaleups and learn how their solutions impact your business!

Staying ahead of the technology curve means strengthening your competitive advantage. That is why we give you data-driven innovation insights into the biotechnology industry. This time, you get to discover five hand-picked protein engineering startups.

Out of 166, the Global Startup Heat Map highlights 5 Top Protein Engineering Startups

The insights of this data-driven analysis are derived from the Big Data & Artificial Intelligence (AI)-powered StartUs Insights Discovery Platform, covering 2 093 000+ startups & scaleups globally. The platform gives you an exhaustive overview of emerging technologies & relevant startups within a specific field in just a few clicks.

The Global Startup Heat Map below reveals the distribution of the 166 exemplary startups & scaleups we analyzed for this research. Further, it highlights five biotech startups that we hand-picked based on criteria such as founding year, location, funding raised, and more. You get to explore the solutions of these five startups & scaleups in this report. For insights on the other 161 protein engineering solutions, get in touch with us.

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Menten AI advances Quantum Protein Design

Founding Year: 2018
Location: Palo Alto, USA
Funding: USD 4 M
Partner for: Peptide Therapeutics

US-based startup Menten AI uses machine learning (ML) and quantum computing to accelerate drug discovery. The startup’s graph convolutional neural (GCN) library allows users to design proteins and encode edge attributes. Quantum computing allows for a high degree of parallelism to model multiple protein molecule solutions simultaneously. Menten AI’s Hybrid Quantum-Classical thus lowers the protein design time for therapies and treatments from months to a few weeks.

ProteinQure provides a Structure-based Drug Design Platform

Founding Year: 2017
Location: Toronto, Canada
Funding: USD 4,6 M
Partner for: Protein Therapeutics

Canadian startup ProteinQure advances structure-based drug design using molecular simulations, ML, and high-performance computing (HPC). The startup’s platform enables proteins engineering that incorporates multiple binding domains to uncover novel peptides for binding, specificity, and other pharmacokinetic properties. Unlike conventional drug discovery solutions, ProteinQure partners with other pharma companies to produce protein therapeutics that are highly specific, targeting a wider range of binding sites, and reducing target effects.

Evozyne develops a Synthetic Gene Library

Founding Year: 2020
Location: Chicago, USA
Funding: USD 54,2 M
Partner for: Plastic Recycling

Evozyne is a US-based startup that develops a data-driven molecular engineering platform to design novel, application-specific proteins. The platform uses genome databases representing the evolutionary record of a target protein to identify and uncover any previously unknown protein rules or functions. After identifying relevant proteins, it explores the data and generates novel sequences predicted by evolution-based computational models. Evozyne’s protein design optimizes multiple parameters to improve all desired parameters at once rather than one at a time.

Sibylla Biotech develops Protein Folding Therapeutics

Founding Year: 2017
Location: Verona, Italy
Funding: USD 2,71 M
Partner for: Preclinical Studies

Italian startup Sibylla Biotech develops a platform to simulate the protein folding pathways for therapeutics discovery. The startup’s technology, pharmacological protein inactivation by folding intermediate targeting (PPI-FIT), finds molecules that would impair the folding of the protein, leading to degradation. It, thereby, achieves a selective reduction of the expression level of the target protein. PPI-FIT also allows drug research and development (R&D) teams to selectively target undruggable proteins.

Heliopolis Biotech offers De Novo Protein Design

Founding Year: 2019
Location: London, UK
Partner for: Drug Discovery

Heliopolis Biotech is a UK-based startup that builds protein designing platforms for R&D. It offers fragment-based de novo protein design of molecules with predetermined backbone architectures and novel folds and sequences. The startup also provides the design of single-domain, high-affinity binders directed against defined conformational epitopes on target proteins and topological rewiring of existing proteins. The startup’s solution accelerates drug discovery pipelines and accelerates preclinical candidates.

Discover more BioTech Startups

BioTech startups such as the examples highlighted in this report focus on novel therapeutics, gene libraries, and drug discovery, as well as quantum computing and advanced analytics. While all of these technologies play a major role in advancing the industry, they only represent the tip of the iceberg. To explore BioTech technologies in more detail, simply let us look into your areas of interest. For a more general overview, download our free BioTech Innovation Report to save your time and improve strategic decision-making.

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