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The healthcare digital twin market is poised for significant growth, with projections indicating an expansion from approximately USD 1.37 billion in 2025 to USD 6.80 billion by 2032. This surge is driven by the increasing adoption of digital twins for personalized medicine, surgical planning, operational optimization, and more.
Leading technology companies, including Siemens Healthineers, Microsoft, and GE Healthcare, are at the forefront of this innovation. Their solutions integrate real-time patient data with advanced analytics to simulate and predict patient outcomes, enhancing decision-making and treatment efficacy. The following article highlights the top healthcare digital twin companies and startups to watch in 2025, showcasing the innovators leading the transformation.
Global Startup Heat Map highlights 10 Healthcare Digital Twin Companies & Startups to Watch
Through the Big Data & Artificial Intelligence (AI)-powered StartUs Insights Discovery Platform, covering over 7M+ startups, 20K+ technology trends, plus 150M+ patents, news articles & market reports, we identified 750 healthcare digital twin companies & startups.
The Global Startup Heat Map below highlights the 10 digital twin healthcare companies you should watch in 2025, as well as the geo-distribution of 750 startups & scaleups we analyzed for this research.
According to our data, we observe high startup activity in the US and India, followed by the UK. The top 5 Startup Hubs for Healthcare Digital Twins are New York City, London, San Francisco, Bangalore, and Singapore.
Discover 10 Emerging Digital Twin Healthcare Startups to Watch in 2025
We hand-picked startups to showcase in this report by filtering for their technology, founding year, location, funding, and other metrics.
Their digital twin healthcare solutions range from personalized health and oncology to digital anatomy.
- ImmuNovus – Human Immune Digital Twin
- DeepCARES – Personalized Health
- Twinical – Oncological Surgery
- Homox – Personal Digital Twin
- AI4LUNGS – Respiratory Disease Care
- DARERL – Digital Anatomy
- Sifio Health – Surgical Aid
- Cyberhuman.AI – Personal Health AI Twin
- CERTAINTY – Personalized Cancer Treatment
- Cardio Intel – Cardiovascular Health
1. ImmuNovus
- Founding Year: 2023
- Location: Lincoln, NE, USA
- Use For: Human Immune Digital Twin
US-based startup ImmuNovus develops a digital twin platform to predict individual immune system trajectories for better health forecasting. It integrates health data from multiple sources, like lab reports or wearable devices, to provide a holistic view of health changes over time.
This allows patients to understand their immune health better. Further, the platform assists clinicians by analyzing integrated patient data and supporting scenario forecasting. This improves diagnostic accuracy and treatment planning.
2. DeepCARES
- Founding Year: 2024
- Location: Jeddah, Saudi Arabia
- Use For: Personalized Health Management
Saudi Arabian startup DeepCARES creates an explainable AI digital twin for the healthcare industry. It implements multi-omics biosensors to collect patient data in real time. The platform then combines sensor data to monitor multiple biomarkers.
This approach facilitates proactive healthcare management for diabetes, hypertension, and cardiac patients through biomarker identification, disease prediction, and reasoning interpretation.
3. Twinical
- Founding Year: 2023
- Location: Paris, France
- Use For: Oncological Surgery
French startup Twinical builds digital twins to assist soft-tissue surgical planning and navigation. Leveraging AI, the platform creates high-fidelity 3D virtual replicas of patient organs. This provides a better understanding of tumor locations and possible surgical complexities.
Further, the platform uses augmented reality (AR) to render organs transparent. This enables surgeons to visualize internal anatomical details and their deformations in real time. The digital twin is also compatible with surgical robots, enhances 3D vision capabilities, and increases overall surgical safety.
4. Homox
- Founding Year: 2023
- Location: Tehran, Iran
- Use For: Personal Digital Twin
Iranian startup Homox offers personal digital twins (PDTs) of individuals by integrating data from wearables, genetic tests, medical history, and more. It utilizes AI algorithms to continuously match all received data with comparable patient data sets to predict patients’ future health.
These PDTs provide real-time health monitoring and decision support. Moreover, PDTs assist pharmaceutical brands in virtually testing new medicines before clinical trials. This allows researchers to predict the efficacy and side effects earlier in the pipeline.
5. AI4LUNGS
- Founding Year: 2024
- Location: Porto, Portugal
- Use For: Respiratory Disease Care
Portuguese startup AI4LUNGS provides a patient-specific digital twin for people with respiratory diseases. The digital twin embeds patient health data from multiple sources and simulates health conditions. It supports clinicians in patient stratification by providing insights into the disease progression and treatment responses.
This enables the development of personalized medicine by allowing doctors to identify which interventions are effective for each patient. It also saves time in clinical decision-making by reducing unnecessary examinations.
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6. DARERL
- Founding Year: 2024
- Location: Copenhagen, Denmark
- Use For: Digital Anatomy
Danish startup DARERL creates a SaaS platform that simulates human anatomy. It uses real human data to create a digital twin of body parts for wearable and medical device designing and testing.
This ensures that the device designs meet anatomical standards and improve patient safety. The platform’s scalability and rapid iteration further allow developers to test variations and accelerate development cycles.
7. Sifio Health
- Founding Year: 2023
- Location: Waterloo, Canada
- Use For: Surgical Management
Canadian startup Sifio Health develops a perioperative digital twin platform to enhance surgical operations. It mirrors the real-world surgical workflow by integrating data from operating rooms, scheduling systems, and staffing records.
Using machine learning, the solution delivers insights into balancing workloads across perioperative departments and ensures optimal use of staff and assets. It also simulates future surgical scenarios for proactively adjusting surgical schedules and resource allocation.
8. Cyberhuman.AI
- Founding Year: 2024
- Location: New York City, NY, USA
- Use For: Health Expertise AI Twin
US-based startup Cyberhuman.AI offers AI-driven digital twins of health and well-being experts to make wellness guidance accessible to all users. One of its solutions, DeepakChopra.AI, provides users with personalized advice and insights based on the expert’s methodologies.
Another AI twin, NonLocal.AI, leverages agentic AI to offer personalized wellness support to users. It is trained on the knowledge of global health professionals. This allows users to access health expertise easily and make informed decisions regarding their health.
9. CERTAINTY
- Founding Year: 2024
- Location: Munich, Germany
- Use For: Personalized Cancer Treatment
German startup CERTAINTY provides a digital twin platform for cancer patients. It simulates disease progression and treatment response by integrating the patient’s clinical and cellular data.
By continuously updating with new patient information, it provides clinicians with predictive insights to tailor therapies. This aids in decision support, especially for blood cancer patients undergoing chimeric antigen receptor (CAR) T-cell therapy.
10. Cardio Intel
- Founding Year: 2021
- Location: Aberdeen, Scotland
- Use For: Cardiovascular Health
Scottish startup Cardio Intel develops a digital twin of a patient’s heart by integrating data from medical scans and wearable devices. Using AI, the startup’s platform enables early detection of cardiovascular issues and supports treatment strategies.
Patients also access their digital heart via mobile devices. This allows for real-time monitoring and proactive management of their cardiovascular health.
Discover All Emerging Healthcare Startups
The healthcare startups showcased in this report are only a small sample of all the startups we identified through our data-driven startup scouting approach. Download our free Healthcare Innovation Report for a broad overview of the industry or get in touch for quick & exhaustive research on the latest technologies & emerging solutions that will impact your company in 2025!
