Staying ahead of the technology curve means strengthening your competitive advantage. That is why we give you data-driven innovation insights into the healthcare sector. This time, you get to discover 5 hand-picked startups developing regenerative gel solutions.
Global Startup Heat Map highlights 5 Top Regenerative Gel Solutions out of 106
The insights of this data-driven analysis are derived from the Big Data & Artificial Intelligence-powered StartUs Insights Discovery Platform, covering 1.379.000+ startups & scaleups globally. The platform gives you an exhaustive overview of emerging technologies & relevant startups within a specific field in just a few clicks.
The Global Startup Heat Map below reveals the distribution of the 106 exemplary startups & scaleups we analyzed for this research. Further, it highlights 5 startups that we hand-picked based on criteria such as founding year, location, funding raised, and more. You get to explore the solutions of these 5 startups & scaleups in this report. For insights on the other 101 regenerative gel solutions, get in touch.
XCell Biogenix develops Regenerative Wound Healing Technology
Wound healing after trauma, surgery, and chronic illness affects millions of people every year. Regenerative medicine plays an important role in wound care. Several cell-based therapeutic solutions increase the rate of wound healing. For example, amnion membranes have cytokines and essential growth factors, and antibacterial properties, in addition to being non-immunogenic. This technology provides a biological barrier or a matrix for the migration and proliferation of cells.
XCell Biogenix is a US-based startup that develops amnion-derived technologies for tissue regeneration to treat wounds and burns. The startup’s Amnion Membrane Technology (XCELL AMT) is derived from mammalian amnion membrane and contains cytokines, extracellular matrix (ECM)-associated proteins, as well as cell factors that are lost during decellularization. As XCELL AMT is not derived from live cells, it does not elicit an immunogenic reaction. The hydrogel product candidate functions and supports the release of stem cell-derived paracrine factors that speed up the process of wound healing.
SolasCure produces a Maggot-based Hydrogel
Medicinal maggots are used in biotherapy, or maggot therapy, for wound treatment. The therapy involves the introduction of disinfected maggots to the non-healing wound to remove the necrotic or dead tissue within a wound. This therapy is limited to use in only particular types of wounds that provide an environment to maggot for feeding. Maggots secrete critical enzymes, which facilitate the debridement and disinfection process. A bio-based gel composed of such enzymes aids in treating chronic wounds.
British startup SolasCure produces active and highly-specific enzyme-based hydrogel. It utilizes enzymes cloned in and extracted from medical maggots. The product assists in chronic wound treatment and wound management. The natural enzyme-based hydrogel offers an alternative to painful, surgical and autolytic debridement procedures.
BoneSci Bio builds Bone Therapy Scaffold
Bones have a limited self-healing capability and thus require external intervention. Techniques like allograft and autograft have inherent disadvantages like donor site morbidity, restricted bone availability, and graft resorption, which demands a newer technology for use. Hydrogel-based bone regeneration provides high mechanical strength, biomimicry of natural extracellular matrix (ECM), and more. This opens up applications of hydrogels as bone growth enhancers and drug delivery systems.
BoneSci Bio is an Israeli startup that develops PeptOss, an amphiphilic and anionic beta-sheet peptide hydrogel. The hydrogel mimics bone biomineralization proteins like osteopontin and bone sialoprotein, among others, to treat bones by promoting the formation and repair of their tissue. PeptOss acts as a drug carrier that releases an antibiotic drug directly to the bone over a few weeks. It strengthens osteoporotic bones to prevent high-risk hip fractures. It also acts as a carrier for chemotherapeutic drugs for the treatment of osteosarcoma.
Renovos Biologics creates Nanoclay Gels
Stem cell therapy cures diseased sites by regenerating the cells and tissues. The objective of any cell therapy is to localize and retain the active biomolecules in close proximity to the healing site. This ensures an increase in the safety and efficacy of regenerative medicine applications. HealthTech startups are working on solutions like nanoclay gels to enhance localized delivery and molecule retention.
Renovos Biologics is a British startup creating synthetic nanoclay gel technology. The startup’s Renovite platform acts as a scaffold and provides a localized environment conducive to cell attachment and infiltration. It localizes and retains molecules which are then used at ultra-low doses. The startup’s Renovite BMP-2 gel offers injectable delivery and retention of bone morphogenetic protein 2 (BMP-2). It finds applications in spinal fusion, treatment of bone defects, and ankle surgery for effective and localized bone formation.
Matricelf develops Regenerative Hydrogel Platform
Spinal cord injuries are traumatic neurological disorders and one of the most difficult conditions to treat in a clinical setting. Regenerative medicine and related technologies play an integral role in treating spinal injuries and other neurological disorders, such as age-related macular degeneration (AMD) and Parkinson’s. MedTech startups are working on platform technologies that extract patient cells to produce personalized hydrogel. This shows promise for the treatment of a wide spectrum of neurological disorders without the need for donors.
Matricelf is an Israeli startup developing autologous engineered tissue. It utilizes matrix and cells derived from omental biopsies. Matricelf’s proprietary decellularization process separates stromal cells and the ECM from the biopsy sample, transforming the latter into a thermo-responsive hydrogel. It reprograms the stromal cells into induced pluripotent stem cells (iPSCs) which are then incorporated into the hydrogel. On administration, these cells differentiate into the desired functional tissues. The gel, on combining with motor neurons, creates functional spinal cord implants to bridge injured spinal cord tissue.
Discover more Healthcare Startups
Healthcare tartups such as the examples highlighted in this report focus on oncology, regenerative medicine, and cell and gene therapies. While all of these technologies play a major role in advancing the healthcare industry, they only represent the tip of the iceberg. To explore more healthcare technologies, simply get in touch to let us look into your areas of interest. For a more general overview, you can download one of our free Healthcare Innovation Report to save your time and improve strategic decision-making.