Staying ahead of the technology curve means strengthening your competitive advantage. That is why we give you data-driven innovation insights into the healthcare sector. This time, you get to discover 5 hand-picked startups developing Heart Failure solutions.
Global Startup Heat Map: 5 Top HealthTech Startups tackling Heart Failure
The 5 healthcare startups you will explore below are chosen based on our data-driven startup scouting approach, taking into account factors such as location, founding year, and relevance of technology, among others. This analysis is based on the Big Data & Artificial Intelligence (AI)-powered StartUs Insights Discovery Platform, covering over 1.3 million startups & scaleups globally.
The Global Startup Heat Map below highlights the 5 healthcare startups & scaleups our Innovation Researchers curated for this report. Moreover, you get insights into regions that observe a high startup activity and the global geographic distribution of the 798 companies we analyzed for this specific topic.
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Restore Medical creates a Catheter-delivered Implant
Congestive heart failure (CHF) leads to more hospitalizations than many cancers. Moreover, it causes significant hospital costs because it is either overlooked or patients need to be readmitted. The use of continuous pulmonary artery (PA) pressure through catheter-delivered implants makes it easy to manage CHF patients. Once implanted, the sensor wirelessly sends pressure readings to the patient’s electronic health record (EHR).
Restore Medical, an Israeli startup, develops a device for congestive heart failure. ContraBand is a catheter-delivered implant for the treatment of left ventricle (LV) failure in patients with preserved right ventricle function. It improves LV ejection fraction, reduces mitral regurgitation, and restores favorable ventricular geometry. ContraBand improves patients’ quality of life and reduces hospital readmission rates.
Metcela specializes in Cardiac Cell Therapy
The pathogenesis of cardiomyopathy and heart failure (HF) occurs by complex changes in the ventricular myocardium. A heart transplant is the standard treatment procedure for HF. However, it is an epidemiologically inconsequential therapy due to a low number of available donor hearts. Regenerative therapy is a novel therapeutic strategy for advanced ischemic heart disease. The cell-based therapy involves transplanted immature progenitor cells that produce new blood vessels and cardiac muscle cells.
Japanese startup Metcela develops a treatment for heart disease patients. The company’s lead candidate, MTC001, is a cell therapy that re-establishes a favorable microenvironment and repairs damaged heart tissue. Metcela’s therapy uses specific fibroblast cells obtained from the patient’s heart that repair the damage by enhancing the cells’ ability to heal. The startup’s solution provides patients an effective and reasonably-priced cure for heart failure.
Oracle Health provides an Implantable Cardiac Monitor
Continuous or intermittent cardiac monitoring helps doctors determine whether arrhythmias or other cardiovascular symptoms. However, the long-term ambulatory electrocardiogram (AECG) monitoring in cardiovascular disease is hampered by the lack of suitable equipment and inadequate patient compliance. Implantable cardiac monitors (ICMs), however, continuously monitor the patient’s electrocardiogram and perform real-time analysis of the heart rhythm for up to 36 months.
Oracle Health is a US-based startup developing a heart failure monitoring system to detect heart failure and cardiac arrhythmia. It utilizes an electrocardiogram (ECG) and pattern recognition and machine learning (ML) algorithms to monitor heart failure progression by analyzing changes in heart sounds and rhythms. The sub-skin implant device has a battery that lasts for 3 years and is compliant for long term monitoring. The device records multiple parameters such as ECG for heart rhythms, phonocardiogram (PCG) for heart sounds, seismocardiography (SCG) for cardiac pressure, and accelerometer for activity.
ESN Cleer develops a Hand-held Medical Nanotech Device
Miniaturized electronics enable the development of more reliable and adaptable portable health devices. Startups are developing portable biosensors that collect medical data from body fluids like blood, saliva, and sweat. Monitoring patients through saliva is a somewhat nuanced approach to diagnostics, but the method has been gaining market traction in recent years.
Australian startup ESN Cleer provides patented nanotechnology-enabled sensors for the prevention of heart attacks. The startup develops a stick-like, hand-held medical nanotech device that collects saliva from a user and measures biomarkers for the potential of disease development. The device comes in two parts: an electronic handle and a disposable sensor that can be easily detached. Their products include an EHF-Test Kit and EHF-ESwab, and saliva-based in vitro diagnostic devices for qualitative detection.
Cardionyx works on a Smart Micropump
Heart failure is one of the leading causes of death with aging, poor diet, and lifestyle choices being major causative factors. The treatment for the later stages of HF is mostly surgical, requires hospitalization, and is a financial burden on healthcare systems. Despite the heart transplant being the gold standard, it suffers from a lack of donor availability and graft rejection. A rising number of medical devices offer affordable and convenient options to manage heart failure.
Israeli startup Cardionyx develops a next-generation miniature heart pump. The pump is affordable, efficient, and implanted through catheterization by using an endovascular procedure with minimal peri-procedural recovery and complications. It has a novel design featuring minimal-shear impellers powered by a magnetic drive and serves class IV HF patients. Further, the startup’s proprietary auto-regulation algorithm matches pump output and flow patterns to patient demands in real-time.
Discover more Healthcare Startups
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