Staying ahead of the technology curve means strengthening your competitive advantage. That is why we give you data-driven innovation insights into the BioTech industry. This time, you get to discover 5 hand-picked systems biology solutions.
Global Startup Heat Map highlights 5 Top Systems Biology Solutions out of 385
The insights of this data-driven analysis are derived from the Big Data & Artificial Intelligence-powered StartUs Insights Discovery Platform, covering 2.093.000+ startups & scaleups globally. The platform gives you an exhaustive overview of emerging technologies & relevant startups within a specific field in just a few clicks.
The Global Startup Heat Map below reveals the distribution of the 385 exemplary startups & scaleups we analyzed for this research. Further, it highlights 5 BioTech startups that we hand-picked based on criteria such as founding year, location, funding raised, and more. You get to explore the solutions of these 5 startups & scaleups in this report. For insights on the other 380 systems biology solutions, get in touch.
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Imagindairy accelerates Cellular Agriculture
Cellular agriculture is rapidly instating itself as a modern ailment to various challenges especially with regards to meat production. Traditional meat processing is resource-intensive, unsustainable, and presents ethical concerns. Synthetically constructing proteins, fats, and tissues provides a sustainable alternative to meat production. However, cellular agriculture is limited by the lack of insights on cellular interactions, growth parameters, and other important factors. Because of this, startups develop systems biology tools that optimize processing and enable the development of new formulations for cellular agriculture.
Israeli startup Imagindairy integrates AI with systems biology to accelerate innovations in cellular agriculture. The startup’s proprietary computational technology increases the expression of milk proteins in microflora. It leverages a cyclical process that involves iterating between optimizing protein expression systems, modeling these systems, and biological implementation of the systems to deliver high protein expression. The startup integrates systems and synthetic biology to optimize milk protein production. Imagindairy’s product is an environmentally friendly, protein-rich, and cost-effective dairy alternative.
InterAx Biotech provides G Protein-Coupled Receptor (GPCR) Drug Discovery
GPCRs continue to provide insights into many diseases. These range from mental and immunological disorders to metabolic disorders and cancers. With advancements in computational power, startups are leveraging bioinformatics and systems biology to discover novel drugs. For example, startups apply pharmacology, biology, and mathematics to accelerate lead generation in drug discovery. They achieve this by modeling existing biological systems and incorporating big data analytics in drug discovery.
Swiss startup InterAx Biotech accelerates GPCR drug discovery via systems biology. The startup expresses target GPCRs in cell lines containing signaling biosensors and uses a set of reference ligands to calibrate the signaling responses. Thereafter, the startup generates mathematical models to describe the specific signaling pathways of the target GPCR. The last step is the analysis of the kinetic profiles of the test compounds using a systems biology model. Through this process, the startup significantly reduces the risks, costs, and duration of drug discovery and development of new drugs, and streamlines the process of drug candidate design and selection.
iMean advances Industrial Biotechnology
Network biology plays an important role in industrial biotechnology as it enables the analysis and integration of all the experimental data generated on the complex behavior of living systems. Biological networks provide a mathematical representation of connections between different biological entities. Startups deliver network biology platforms to aid in industrial biotechnology, allowing for insight into different aspects of molecular and cellular information.
French startup iMEAN aids industrial biotechnology through network biology. The startup provides a modeling platform and manual curation services, to deliver mathematical models of living cells, such as genome-scale metabolic networks or kinetics models. The startup further performs in silico combinatorial studies to determine metabolic engineering strategies that ensure cellular homeostasis. The startup’s design service alleviates competitive fluxes, generates new-to-nature pathways, and delivers scalable solutions. iMean also provides solutions for agricultural and academic biotechnology.
Tiaki Therapeutics performs Neuroinflammatory Disease Modeling
Neuroinflammatory diseases, such as Alzheimer’s disease, impact the central nervous system (CNS) and are highly researched, but have few cures. A lack of computational approaches and systems modeling makes research into neuroinflammation evasive, as each patient leaves unique residual proteins, denying these diseases to be approached from a reductionist approach. This is why startups engineer disease modeling using systems biology, along with bioinformatics, to gain insights into neuroinflammation.
US-based startup Tiaki Therapeutics models diseases to gain insight into neuroinflammation. The startup’s proprietary systems biology platform reveals novel targets for neurodegenerative diseases to enable the development of patient-specific treatments for these diseases. The platform utilizes human datasets and bioinformatics to provide new insights into dysregulated neuroinflammatory pathways. These insights uncover druggable targets that reverse the neuroinflammatory signatures, as well as reveal biomarkers that accelerate drug development.
BioStrand offers Crop Protection Products
Systems biology enables approaching problems from a holistic perspective and this provides many benefits in the agriculture industry. Using synthetic herbicides, insecticides or other plant health products results in poorer yields in the long run. Moreover, it poses the risk of biomagnification of harmful chemicals. Using systems biology helps startups develop novel plant protection products that reduce or eliminate this effect in plants and ensure healthy crops. For example, bioinformatics and big data assist in modeling new compounds and products tailored to specific regions and plants.
BioStrand is a Belgian startup developing crop protection products. The startup’s AI-based platform combines graph-based data mining with the startup’s HYFTs database. The database comprises signature sequences across species that serve as structural anchor points and carry a multitude of information layers. This enables the startup to pinpoint very specific targets for the microbiome research and development of crop protection products. Additionally, BioStrand uses its platform to develop solutions for the pharmaceutical, biotech, cosmetics, and food technology sectors as well.
Discover more BioTech startups
BioTech startups such as the examples highlighted in this report focus on synthetic biology, biomanufacturing, and metabolic engineering. While all of these technologies play a major role in advancing the BioTech industry, they only represent the tip of the iceberg. To explore more BioTech technologies, simply get in touch to let us look into your areas of interest. For a more general overview, you can download our free BioTech Innovation Report to save your time and improve strategic decision-making.
