10 Top Digital Twin Startups and Companies for Industry 4.0 [2025]

As Industry 4.0 reshapes manufacturing, energy, logistics, and infrastructure, digital twin startups are capturing executive attention, with the global market expected to reach USD 119.8 billion by 2029.  These digital twin startups for industry 4.0 – like Toobler (India) and Twinsity (Germany) – are pioneering Internet of Things (IoT), artificial intelligence (AI), and 3D‑powered virtual replicas to reduce downtime, predict failures, optimize resource use, and accelerate new asset roll‑outs.

For business leaders, operations heads, and investors, tracking these high-growth startups means uncovering high-impact tools that drive efficiency, resilience, and data‑driven decision-making.

Global Startup Heat Map highlights 10 Digital Twin Startups & Companies advancing Industry 4.0

Through the Big Data & Artificial Intelligence (AI)-powered StartUs Insights Discovery Platform, covering over 7M+ startups, 20K+ technology trends, plus 150M+ patents, news articles & market reports, we identified 910 industry 4.0 digital twin startups.

The Global Startup Heat Map below highlights the 10 industry 4.0 digital twin startups you should watch in 2025, as well as the geo-distribution of 910 startups & scaleups we analyzed for this research.

According to our data, we observe high startup activity in the US and India, followed by Germany and the UK. The top 5 Startup Hubs for Digital Twins Solutions advancing Industry 4.0 are Bangalore, London, Dubai, San Francisco, and New York City.

Download High-Res Visual

Share this:

• Facebook
• X
• LinkedIn

Explore Emerging Digital Twin Startups advancing Industry 4.0 [2025]

We hand-picked startups to showcase in this report by filtering for their technology, founding year, location, funding, and other metrics.

These industry 4.0 digital twin startups work on solutions ranging from asset management and production planning to industrial walkthroughs and business planning.

1. ProtoTwin – Prototype Simulation
2. SIMCEL – Integrated Business Planning (IBP)
3. The Digital Twin – Industrial Virtual Walk Throughs
4. Thingspine – Construction Optimization
5. Twinstory – Digital Collectibles
6. Re-Twin Energy – Energy Storage Returns Maximization
7. Model One – Digital Twins for Electrochemical Devices
8. Geminum – Mining and Heavy Asset Digital Twins
9. clevertwin – Asset Management
10. nextMO – Production Planning

1. ProtoTwin

• Founding Year: 2023
• Location: London, UK
• Use For: Prototype Simulation

UK-based startup ProtoTwin develops browser-based industrial simulation software. It allows manufacturers to create digital prototypes of industrial machines and robots before manufacturing physical prototypes.

The software allows early detection of issues in the design phase. It also allows designers to optimize and validate control logic with scripting. Engineers in robotics, automation, and manufacturing use it to refine systems before deployment and minimize associated costs.

2. SIMCEL

• Founding Year: 2023
• Location: Singapore
• Use For: Integrated Business Planning

Singaporean startup SIMCEL facilitates integrated business planning using digital twin technology. The company’s AI-powered digital twin platform features dynamic scenario simulation, activity-based costing, and carbon modeling.

It provides real-time insights across supply, demand, finance, and sustainability factors of a supply chain. Manufacturers, retailers, and other stakeholders generate what-if scenarios to test uncertainties and optimize operations based on profitable outcomes.

3. The Digital Twin

• Founding Year: 2024
• Location: Cape Town, South Africa
• Use For: Industrial Virtual Walk Throughs

South African startup The Digital Twin creates digital replicas of industrial equipment and facilities. The digital twins enable predictive maintenance, virtual site visits, and remote monitoring. This reduces unplanned downtime and maintenance costs.

The startup also develops DigiTags, its interactive markers, with the digital twins’ virtual walk-throughs. They provide real-time access to critical information and enhance operational efficiency.

4. Thingspine

• Founding Year: 2023
• Location: San Francisco, CA, USA
• Use For: Construction Optimization

US-based startup Thingspine offers a digital twin builder platform that combines a digital twin, IoT, and data middleware for construction management.

The platform creates 2D and 3D visual models using live industrial data streams sourced from IoT sensors. This allows continuous monitoring of physical assets and operations through real-time data feeds.

As a result, industrial workers have immediate visibility into operational conditions and achieve faster response times.

5. Twinstory

• Founding Year: 2024
• Location: Amsterdam, Netherlands
• Use For: Digital Collectibles

Dutch startup Twinstory develops digital twins of physical collectibles and product certificates. By scanning a quick response (QR) code, product owners claim a non-fungible token (NFT) via email or wallet for proof of authenticity and ownership.

Using this, product manufacturers, collectible brands, and retail companies create digital twins of products and machines for virtual commissioning.

This avoids the risks of losing or falsifying physical certificates. The startup’s approach improves resale value for industries like electronics, fashion, construction, and manufacturing.

Want to Explore 900+ Digital Twin Companies advancing Industry 4.0?

6. Re-Twin Energy

• Founding Year: 2025
• Location: Berlin, Germany
• Use For: Energy Storage Returns Maximization

German startup Re-Twin Energy provides a digital twin platform to maximize the returns of energy storage assets. Utilizing AI-driven analytics, it simulates different market scenarios to aid in investment analysis and virtual power trading.

The platform features multi-asset trading simulation, scenario analysis, asset performance benchmarking, back-testing, and more. These features facilitate decision-making in power trading and mitigate risks via revenue forecasting.

7. Model One

• Founding Year: 2023
• Location: Norrkoping, Sweden
• Use For: Digital Twins for Electrochemical Devices

Swedish startup Model One offers digital twins of electrochemical devices. It uses Poisson-Nernst-Planck (PNP) equations to simulate the device design and performance of batteries, supercapacitors, fuel cells, electrolyzers, transistors, and sensors.

The startup’s digital twin library, ModElChem, simulates cyclic voltammograms (CV) for electrochemical reaction mechanisms. This includes electron transfer and chemical steps. The library aids researchers and engineers in optimizing battery designs.

8. Geminum

• Founding Year: 2023
• Location: Brisbane, Australia
• Use For: Mining and Heavy Asset Digital Twins

Australian startup Geminum builds digital twins for mining and heavy asset industries. The digital twins integrate data from IoT sensors, cameras, access control, and work management systems to create virtual replicas of industrial assets and processes.

The startup’s improvement twin leverages a constraints model to identify production bottlenecks in real time, minimizing production losses. The safety digital twin also improves situational awareness through real-time visualization of safety-critical operations.

Further, the digital twin for ore operations visualizes exploration data on drill holes, surface samples, models of proposed processes, pit shells, mine sequencing, and more. This provides miners access to available information in real time for enhanced decision support.

9. clevertwin

• Founding Year: 2023
• Location: Barranquilla, Colombia
• Use For: Asset Management

Colombian startup clevertwin develops digital twins for industries like construction, transportation, electricity, oil, gas, water, and defense.

The startup’s CAPTURE platform gathers 3D spatial data utilizing vehicles, camera drones, light detection and ranging (LiDAR), inertial measurement units (IMU), and global positioning systems (GPS). Based on this data, CAPTURE creates a digital twin that replicates the physical industrial environment.

Another platform, IDENTIFY, employs AI to analyze these digital twins for monitoring machinery, assets, and more. This enables users to conduct virtual inspections, foresee risks in inaccessible places, and rectify system failures proactively.

10. nextMO

• Founding Year: 2023
• Location: Buren, Germany
• Use For: Production Planning

German startup nextMO enables AI-based production planning for discrete manufacturing. Its digital twin, nextMO SIMULATOR, simulates production processes to optimize future order scenarios.

The platform analyzes data such as the current utilization of machines and workpiece flow to identify potential bottlenecks. This streamlines workflows and reduces downtime. Using AI algorithms, nextMO SIMULATOR also suggests improvements in production facilities to enhance efficiency.

Discover All Emerging Industry 4.0 Startups

The Industry 4.0 startups showcased in this report are only a small sample of all startups we identified through our data-driven startup scouting approach. Download our free Industry 4.0 Innovation Report for a broad overview of the industry or get in touch for quick & exhaustive research on the latest technologies & emerging solutions that will impact your company in 2025!