In 2025, AI simulation startups use technologies like quantum-enhanced AI, neuromorphic computing, edge AI, and federated learning. These enable the creation of virtual environments that predict, optimize, and transform real-world processes across various sectors.
In healthcare, AI simulations personalize treatment plans and predict disease outbreaks, while in manufacturing, they optimize production lines and design new materials. These innovative startups are pushing the boundaries of what’s possible, offering solutions to some of the world’s most pressing challenges and transforming industries in the process.
10 AI Simulation Startups to Watch in 2025
- muchbetter-ai – Simulations with AI-generated clients
- FloodWaive – Intelligent Flood Models and Early Warning Systems
- Phishbite – AI-powered Phishing Simulation Platform
- Trovex.ai – AI-driven Training Platform
- Dentrino AI – Cosmetic Dentistry Virtual Try-on
- Anigma – AI Plastic Surgery Analysis
- Xeureka – Computational and Experimental Drug Discovery
- UnravelX – Instant 3D Training Simulations & Assessments
- Moxso – AI-based Phishing Simulation
- Ambr – Management Development
Global Startup Heat Map highlights 10 AI Simulation Startups to Watch
Through the Big Data & Artificial Intelligence (AI)-powered StartUs Insights Discovery Platform, covering over 5M+ startups & scaleups globally alongside 20K+ technologies & trends, we identified 150+ AI simulation startups.
The Global Startup Heat Map below highlights the 10 AI simulation startups you should watch in 2025 as well as the geo-distribution of 150+ startups & scaleups we analyzed for this research.
Based on the heat map, we see high startup activity in Western Europe and the United States, followed by India.
We hand-picked startups to showcase in this report by filtering for their technology, founding year, location, funding, and other metrics.
These AI simulation startups work on solutions ranging from surgery analysis and phishing prevention to training simulations and drug discovery.
Moreover, based on the data from the platform, the Top 5 AI Simulation Startup Hubs are in London, San Francisco, New York City, Bangalore, and Los Angeles.
Explore 10 AI Simulation Startups to Watch in 2025
1. muchbetter.ai
- Founding Year: 2023
- Location: Paris, France
- Solution: Sales Training
French startup muchbetter.ai develops AI-driven simulations for sales training to advance sales teams’ practice and skill refining. The platform simulates actual customer encounters using AI-generated role-playing situations to emphasize critical skills like active listening, bargaining strategies, and resolving objections.
It allows salespeople to interact with AI-powered clients that change dynamically in reaction to the responses which provide a realistic and engaging learning environment. It provides managers with comprehensive data, such as session recordings, performance evaluations, and actionable insights to track team and individual success.
Muchbetter.ai benefits sales teams in closing competency gaps, making better decisions, and performing better by offering constant feedback and quantifiable results.
2. FloodWaive
- Founding Year: 2023
- Location: Aachen, Germany
- Solution: Disaster Prevention
German startup FloodWaive creates AI-powered intelligent flood modeling and early warning solutions to forecast, track, and reduce flood risks. Its models provide correct and dynamic flood forecasts and risk assessments by combining real-time hydrological, meteorological, and topographical data.
The technology enables enterprises, government organizations, and infrastructure planners to put proactive mitigation measures into place by producing automatic alerts and high-resolution flood maps.
FloodWaive’s scalable and adaptable technology lessens the financial and environmental harm that floods bring while improving disaster preparedness. It promotes climate resilience and aids communities in effectively responding to rising flood hazards by fusing predictive analytics with actionable insights.
3. Phishbite
- Founding Year: 2023
- Location: Tallinn, Estonia
- Solution: Protection from Phishing Attempts
Estonia based startup Phishbite enables businesses to improve human-layer protection against phishing attempts by providing an AI-powered phishing simulation and cybersecurity awareness platform. The technology constantly generates realistic phishing simulations based on organizational risk factors, cultural context, and individual employee behavior using AI.
It offers prompt and useful feedback on how workers handled the simulated attacks to promote ongoing education and skill development. It provides employers with team resilience levels, vulnerability hotspots, and risk patterns from detailed analytics.
Phishbite lowers the risk of data breaches and organizational exposure to phishing attacks by automating security training procedures and providing a proactive cybersecurity culture.
4. Trovex.ai
- Founding Year: 2023
- Location: Bangalore, India
- Solution: Workforce Training
Indian startup Trovex.ai provides an AI-powered workforce training platform that uses interactive simulations and adaptive learning to improve employee performance and skill development. The platform customizes content to meet each learner’s unique needs by examining role requirements, present skill levels, and real-time performance data.
Trovex.ai offers employees practical learning chances in a virtual setting by integrating real-world scenarios that mimic organizational difficulties. It allows managers to monitor development, spot knowledge gaps, and match training results to strategic goals with the help of advanced analytics and dashboards.
The startup enables businesses to boost productivity, expedite workforce upskilling, and equip teams to tackle changing business issues by integrating immersive simulations and customized learning pathways.
5. Dentrino AI
- Founding Year: 2022
- Location: Toronto, Canada
- Solution: Dentistry Treatment Enhancement
Canadian startup Dentrino AI offers a virtual try-on solution for cosmetic dentistry that employs AI to model possible dental treatment outcomes. The technology creates realistic previews for cosmetic procedures including veneers, orthodontics, and teeth whitening by utilizing advanced picture processing and facial analysis.
It allows dentists to use the tool to show potential treatments, modify simulations in real time, and match patient expectations with realistic outcomes during consultations.
Dentrino AI improves patient-dentist communication, raises treatment acceptance rates, and improves overall satisfaction in cosmetic dentistry practices by facilitating visual clarity and enabling informed decision-making.
Interested in exploring all 155 AI Simulation startups & scaleups?
6. Anigma
- Founding Year: 2022
- Location: Yuseong-gu, South Korea
- Solution: Visual Forecasts for Plastic Surgery
South Korean startup Anigma specializes in AI-powered imaging solutions for aesthetic and plastic surgery by offering advanced tools for consultation and planning. Its software provides automated measures and correct visual forecasts for surgeries like rhinoplasty, facelifts, and contouring by analyzing high-resolution patient photos to simulate possible surgical outcomes.
Anigma creates anatomically correct simulations that meet clinical standards and patient objectives by utilizing machine learning techniques. It benefits clinics by increasing consultation efficiency with clear and data-backed visuals.
The startup improves the caliber of pre-operative planning and ensures better outcomes for aestheticians and patients by fusing automation and accuracy.
7. Xeureka
- Founding Year: 2021
- Location: Tokyo, Japan
- Solution: Speed-up Drug Discovery
Japanese startup Xeureka’s AI-powered computational platform combines molecular simulation and machine learning technologies to advance drug discovery. The technology speeds up the discovery process by identifying and optimizing drug candidates using data-driven modeling and virtual screening.
Xeureka employs advanced techniques like free energy perturbation (FEP) to determine molecule binding energies and reduce experimental iterations and related expenses. The technology enables pharmaceutical companies to improve lead optimization, rank promising candidates, and investigate intricate chemical interactions.
The startup advances treatments by providing effective and high-accuracy solutions that increase pre-clinical and clinical research success rates.
8. UnravelX
- Founding Year: 2021
- Location: Singapore
- Solution: Workforce Development
Singaporean startup UnravelX offers a 3D training simulation platform that enables organizations to create immersive, role-specific virtual training environments. It is beneficial for businesses to upload and convert training materials into lifelike 3D simulations. These are suited to industry-specific problems like customer service, emergency response, and compliance scenarios.
UnravelX uses AI-driven automation to create interactive settings where workers can hone important skills, get immediate feedback, and test their ability to make decisions under duress. To analyze results, pinpoint shortcomings, and increase training effectiveness, managers use performance analytics.
The startup increases learning, retention, and workforce readiness by fusing practical experience with quantifiable insights.
9. Moxso
- Founding Year: 2021
- Location: Copenhagen, Denmark
- Solution: Phishing Prevention
Denmark-based startup Moxso creates a cybersecurity training platform and phishing simulation using AI. The technology creates customized as well as realistic phishing situations that dynamically adjust to the behavior and vulnerabilities of each employee.
The startup analyses answers when employees fail simulations and offers them focused learning materials with practical advice. Employers address employees’ weak points using risk assessments, behavioral patterns, and resilience scores.
Moxso creates a proactive cybersecurity culture that counters phishing attempts and lowers the risk of human error. Moxso also raised USD 1.56 million to accelerate its human-layered cybersecurity.
10. Ambr
- Founding Year: 2022
- Location: London, United Kingdom
- Solution: Leadership Development Training
UK-based startup Ambr offers a voice-based AI platform for management development. It simulates challenging workplace conversations to build leadership communication skills. The software allows managers to practice performance evaluations, dispute resolution, and deliver feedback by using AI to generate realistic voice-driven situations.
It analyzes tone, linguistic clarity, and conversational flow in real time and delivers useful comments for enhancement. The startup equips managers to handle intricate interpersonal dynamics, fortify team bonds, and enhance overall workplace performance.
Discover All Emerging AI Simulation Startups
The 10 AI simulation startups showcased in this report are only a small sample of all startups we identified through our data-driven startup scouting approach.
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